• Corpus ID: 37111536

Effect of praziquantel on the cardiotonic action of cardiac glycosides.

@article{Khayyal1987EffectOP,
  title={Effect of praziquantel on the cardiotonic action of cardiac glycosides.},
  author={Mohamed T. Khayyal and Samira M. Saleh and P. Schlieper and H. Tawfik},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1987},
  volume={286 1},
  pages={
          85-96
        }
}
  • M. KhayyalS. Saleh H. Tawfik
  • Published 1 March 1987
  • Biology, Medicine, Chemistry
  • Archives internationales de pharmacodynamie et de therapie
The effect of praziquantel on isolated left guinea-pig atria has been studied. Praziquantel caused a concentration-dependent increase in the force of contraction of the isolated left atria, an effect which may be due to an increase in Ca++ fluxes. Praziquantel antagonized the cardiotonic effect of cardiac glycosides on guinea-pig atria. This antagonism is neither due to an alteration of Ca++ concentration in the cell, nor to a direct action on Na+, K+-ATPase, nor to inhibition of the binding of…