Effect of postnatal anoxia on seizure susceptibility in rats: bicuculline-induced seizures and pretreatment with iproniazid.

The effects of anoxia at 10 days of age on seizures induced by bicuculline (BIC), a specific antagonist of gamma-aminobutyric acid (GABA), and BIC-induced seizures after pretreatment with iproniazid (IPR), a monoamine oxidase inhibitor, were investigated in male adult rats. The rats with postnatal anoxia (Group A) were significantly more susceptible to BIC… CONTINUE READING