Effect of porcine respiratory coronavirus infection on lipopolysaccharide recognition proteins and haptoglobin levels in the lungs.

@article{Gucht2006EffectOP,
  title={Effect of porcine respiratory coronavirus infection on lipopolysaccharide recognition proteins and haptoglobin levels in the lungs.},
  author={Steven Van Gucht and Kalina R Atanasova and Filip Barb{\'e} and Eric Cox and Maurice B Pensaert and Kristien van Reeth},
  journal={Microbes and infection},
  year={2006},
  volume={8 6},
  pages={1492-501}
}
Porcine respiratory coronavirus (PRCV) potentiates respiratory disease and proinflammatory cytokine production in the lungs upon intratracheal inoculation with lipopolysaccharide (LPS) at 1 day of infection. This study aimed to quantify LPS-binding protein (LBP), CD14 and haptoglobin in the lungs throughout a PRCV infection. LBP and CD14 recognize LPS and enhance its endotoxic activity, whereas haptoglobin dampens it. Gnotobiotic pigs were inoculated intratracheally with PRCV (n = 34) or saline… CONTINUE READING

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