Effect of polymyxin B on gram-negative bacterial infection during pregnancy.

@article{Jaiswal2011EffectOP,
  title={Effect of polymyxin B on gram-negative bacterial infection during pregnancy.},
  author={Mukesh Kumar Jaiswal and Varkha Agrawal and Yogesh Kumar Jaiswal},
  journal={Journal of the Turkish German Gynecological Association},
  year={2011},
  volume={12 2},
  pages={64-70}
}
OBJECTIVE Polymyxin B (PB) is a naturally occurring cationic cyclic decapeptide which is highly bactericidal to Gram-negative bacteria. The objective of this study was to investigate the effect of PB on the viability of developing embryos during pregnancy and to validate its protective effect on the embryotoxic effect of Gram-negative bacterial lipopolysaccharide (LPS). MATERIAL AND METHODS Animals were injected intraperitoneally (i.p.) with PB (5-100 μg/animal), (Minimum effective dose) MD… CONTINUE READING