Effect of polymorphisms in XRCC1, CCND1 and GSTM1 and tobacco exposure as risk modifier for oral leukoplakia.

@article{Yadav2009EffectOP,
  title={Effect of polymorphisms in XRCC1, CCND1 and GSTM1 and tobacco exposure as risk modifier for oral leukoplakia.},
  author={Binod Kumar Yadav and Jatinder Kaur and Anurag Srivastava and Ranju Ralhan},
  journal={The International journal of biological markers},
  year={2009},
  volume={24 2},
  pages={90-8}
}
Analysis of gene-environment interactions may help to define the risk of oral leukoplakia. We hypothesized that an individual's susceptibility to leukoplakia is dependent on interactions between polymorphic genotypes at susceptible loci and tobacco exposure. To test this hypothesis, the relationship between tobacco use and polymorphisms in 3 genes that might contribute to variance in individuals' susceptibility to the risk of leukoplakia was determined. In this case-control study, polymorphic… CONTINUE READING