Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

@article{Powis1992EffectOP,
  title={Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule},
  author={Simon J. Powis and Edward V. Deverson and W. John Coadweil and Antonio Ciruela and Neville S. Huskisson and Howard G Smith and Geoffrey W Butcher and Jonathan Charles Howard},
  journal={Nature},
  year={1992},
  volume={357},
  pages={211-215}
}
Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex… CONTINUE READING