Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions.

@article{Knopp2016EffectOP,
  title={Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions.},
  author={Matthias Manne Knopp and Nabil Chourak and Fauzan Khan and Johan Wendelboe and Peter Langguth and Thomas Rades and Ren{\'e} Holm},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2016},
  volume={105},
  pages={
          106-14
        }
}
  • Matthias Manne Knopp, Nabil Chourak, +4 authors René Holm
  • Published in
    European journal of…
    2016
  • Chemistry, Medicine
  • This study investigated the non-sink in vitro dissolution behavior and in vivo performance in rats of celecoxib (CCX) amorphous solid dispersions with polyvinyl acetate (PVA), polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) at different drug doses. Both in vitro and in vivo, the amorphous solid dispersions with the hydrophilic polymers PVP and HPMC led to higher areas under both, the in vitro dissolution and the plasma concentration-time curves (AUC) compared to crystalline… CONTINUE READING

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