Effect of polyethyleneglycol (PEG) chain length on the bio-nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells.

@article{Pozzi2014EffectOP,
  title={Effect of polyethyleneglycol (PEG) chain length on the bio-nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells.},
  author={D Pozzi and Valentina Colapicchioni and Giulio Caracciolo and Susy Piovesana and Anna Laura Capriotti and S Palchetti and Stefania De Grossi and Anna Riccioli and Heinz Amenitsch and Aldo Lagan{\`a}},
  journal={Nanoscale},
  year={2014},
  volume={6 5},
  pages={2782-92}
}
When nanoparticles (NPs) enter a physiological environment, medium components compete for binding to the NP surface leading to formation of a rich protein shell known as the "protein corona". Unfortunately, opsonins are also adsorbed. These proteins are immediately recognized by the phagocyte system with rapid clearance of the NPs from the bloodstream. Polyethyleneglycol (PEG) coating of NPs (PEGylation) is the most efficient anti-opsonization strategy. Linear chains of PEG, grafted onto the NP… CONTINUE READING
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