Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action.

@article{Xaplanteri2003EffectOP,
  title={Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action.},
  author={Maria A. Xaplanteri and Athanasios Andreou and George P Dinos and Dimitrios L. Kalpaxis},
  journal={Nucleic acids research},
  year={2003},
  volume={31 17},
  pages={5074-83}
}
Chloramphenicol is thought to interfere competitively with the binding of the aminoacyl-tRNA 3'-terminus to ribosomal A-site. However, noncompetitive or mixed-noncompetitive inhibition, often observed to be dependent on chloramphenicol concentration and ionic conditions, leaves some doubt about the precise mode of action. Here, we examine further the inhibition effect of chloramphenicol, using a model system derived from Escherichia coli in which a peptide bond is formed between puromycin and… CONTINUE READING

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