Effect of polyamines on acidified ethanol-induced gastric lesions in rats.

@article{Mizui1983EffectOP,
  title={Effect of polyamines on acidified ethanol-induced gastric lesions in rats.},
  author={Takuji Mizui and M Doteuchi},
  journal={Japanese journal of pharmacology},
  year={1983},
  volume={33 5},
  pages={939-45}
}
The participation of polyamines and nonprotein sulfhydryls in the gastric cytoprotective mechanisms was studied using gastric mucosal lesions produced by acidified ethanol in rats as an experimental model. Treatment with prostaglandin E2 (PGE2), but not cimetidine, prevented the formation of gastric mucosal lesions. Oral administration of cadaverine, spermidine and spermine prevented the lesion formation by acidified ethanol in a dose-dependent manner. Indomethacin or acetazolamide had no… CONTINUE READING