Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis.

@article{Uchigata1983EffectOP,
  title={Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis.},
  author={Yasuko Uchigata and Hiroyasu Yamamoto and Hitoshi Nagai and Hiroshi Okamoto},
  journal={Diabetes},
  year={1983},
  volume={32 4},
  pages={316-8}
}
Nicotinamide (10 mmol/kg) and 3-aminobenzamide (1.25 mmol/kg), poly(ADP-ribose) synthetase inhibitors, were injected intravenously to rats either 30 min before the intravenous administration of 12 mg/kg alloxan or 50 mg/kg streptozotocin ("pretreatment") or 5 min after the administration ("posttreatment"). Fifteen minutes after the injection of the… CONTINUE READING