Effect of podophyllin lignans on mast cell morphology in rat peritoneal fluid.

@article{Padawer1961EffectOP,
  title={Effect of podophyllin lignans on mast cell morphology in rat peritoneal fluid.},
  author={Jacques Padawer},
  journal={The American journal of physiology},
  year={1961},
  volume={200},
  pages={
          1340-4
        }
}
The morphology of mast cells is affected by podophyllotoxin and related substances. Other nondividing cells respond similarly. The changes observed are cytoplasmic and identical to those demonstrated following treatment with colchicine. Biological activity of podophyllin lignans is referable to specific molecular configuration and, in the mast cell system, parallels their activity in other assays such as tumor damage and mitotic inhibition of regenerating liver. These findings extend those… CONTINUE READING