Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.

@article{Watson1995EffectOP,
  title={Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein.},
  author={Andrew D Watson and Mohamad Navab and Susan Y Hama and Alex Sevanian and Stephen M. Prescott and Diana M. Stafforini and Thomas M McIntyre and Bert N. La Du and Alan M. Fogelman and Judith A. Berliner},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 2},
  pages={774-82}
}
Mildly oxidized low density lipoprotein (MM-LDL) produced by oxidative enzymes or cocultures of human artery wall cells induces endothelial cells to produce monocyte chemotactic protein-1 and to bind monocytes. HDL prevents the formation of MM-LDL by cocultures of artery wall cells. Using albumin treatment and HPLC we have isolated and partially characterized bioactive oxidized phospholipids in MM-LDL. Platelet activating factor-acetylhydrolase (PAF-AH), a serine esterase, hydrolyzes short… CONTINUE READING

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