Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production.

@article{Sario2002EffectOP,
  title={Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production.},
  author={Antonio di Sario and Emanuele Bendia and Gianluca Svegliati Baroni and Francesco Ridolfi and A Casini and Elisabetta Ceni and Stefania Saccomanno and Marco Marzioni and Luciano Trozzi and Paola Sterpetti and Silvia Taffetani and Antonio Benedetti},
  journal={Journal of hepatology},
  year={2002},
  volume={37 5},
  pages={584-91}
}
BACKGROUND/AIMS Pirfenidone has been recently shown to reduce dimethynitrosamine-induced liver fibrosis in the rat, but no information are available on the effect of this drug on cultured hepatic stellate cells (HSC). METHODS HSC proliferation was evaluated by measuring bromodeoxyuridine incorporation; PDGF-receptor autophosphorylation, extracellular signal-regulated kinase (ERK1/2) and pp70(S6K) activation were evaluated by western blot; protein kinase C activation was evaluated by western… CONTINUE READING

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