Effect of piperacillin/tazobactam treatment on human bowel microflora.

  title={Effect of piperacillin/tazobactam treatment on human bowel microflora.},
  author={Carl Erik Nord and B. T. V. Brismar and B Kasholm-Tengve and G. Tunevall},
  journal={The Journal of antimicrobial chemotherapy},
  volume={31 Suppl A},
The effect of piperacillin/tazobactam treatment on the bowel microflora was studied in 20 patients with intra-abdominal infections. The patients were treated with piperacillin 4 g and tazobactam 500 mg administered intravenously every 8 h for four to eight days. Stool specimens were collected before, during and after treatment. Six patients had measurable faecal concentrations of piperacillin (1.2-276 mg/kg) and four patients measurable concentrations of tazobactam (0.8-22.2 mg/kg) during… CONTINUE READING


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