Effect of physical activity on glutamine metabolism

@article{Agostini2010EffectOP,
  title={Effect of physical activity on glutamine metabolism},
  author={Francesco Agostini and Gianni Biolo},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  year={2010},
  volume={13},
  pages={58–64}
}
  • F. Agostini, G. Biolo
  • Published 1 January 2010
  • Biology
  • Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of reviewGlutamine is largely synthesized in skeletal muscles and provides fuel to rapidly dividing cells of the immune system and precursors to gluconeogenesis in the liver. Physical exercise is known to affect glutamine synthesis and to modulate glutamine uptake. Overtraining is frequently associated with reduced availability of glutamine and decreased immunocompetence. Inactivity affects glutamine metabolism, but this subject was poorly investigated. Recent findingsStrenuous physical… 
View on Wolters Kluwer
ncbi.nlm.nih.gov
44 Citations
Highly Influential Citations
6
Background Citations
20
Results Citations
2

44 Citations

Citation Type

Citation Type

Lymphocyte Glucose and Glutamine Metabolism as Targets of the Anti-Inflammatory and Immunomodulatory Effects of Exercise
TLDR
Whether the beneficial effects of exercise on lymphocyte function in health and disease are associated with modulation of the glucose and glutamine metabolic pathways is discussed.
Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting
The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise
TLDR
Results of this study showed that, some biochemical factors are time-dependent and can increase or decrease over time, as well as, serum levels of hs-CRP and MDA decreased with glutamine supplementation along with the increase in the TAC serum levels, but this supplementation had no effect on serum Levels of MMP2 and MMP9 in exhaustive exercise.
Influence of glutamine supplementation on muscle damage and oxidative stress indices following 14km running
TLDR
It seems 7 day glutamine supplementation has been able to affect oxidative stress and muscle damage markers via possibly an effect on antioxidant agents.
Glutamine metabolism in advanced age.
TLDR
Oral glutamine supplementation initiated before advanced age in rats increases gut mass and improves the villus height of mucosa, thereby preventing the gut atrophy encountered in advanced age, and allowed the use of citrulline as a noninvasive marker of intestinal atrophy induced by advanced age.
The Effect of Glutamine Supplementation on Exercise-Induced Oxidative Stress
TLDR
It seems 7day glutamine supplementation has been able to affectoxidative stress markers via possibly effect on antioxidant agents.
New trends in biological aids to recovery after exercise: Immunomodulators
TLDR
The purpose of this review is to provide an update on published research focusing primarily on the efficacy of immunomodulation substances in the recovery of athletes with respect to physical performance.
Importance of exercise immunology in health promotion
TLDR
The hypothesis that exercise may modulate immune functions and the importance of exercise immunology in respect to chronic illnesses, chronic heart failure, malnutrition and inflammation is discussed.
The Effect of Strength Training and Consumption of Glutamine Supplement on GH/IGF1 Axis
TLDR
It is concluded that resistance training at 80-95% 1RM intensity, and resistance training along with oral glutamine shows significantly increase secretion of GH, IGF-1, and IGFBP-III in amateur males, but the addition of oral glutamines to the exercise program did not show significant difference.
Combining Exercise with Glutamine Supplementation in Cancer-Cachexia Metabolism
TLDR
Physical activity contributes to several beneficial processes including the management, treatment and prevention of various diseases, particularly cardiovascular and metabolic diseases, and cancer prevention has been shown to be related to physical activity.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 80 REFERENCES
Effect of glutamine supplementation on changes in the immune system induced by repeated exercise.
TLDR
The hypothesis that those aspects of postexercise immune changes studied are caused by decreased plasma glutamine concentrations does not appear to support the hypothesis.
Blood leukocyte and glutamine fluctuations after eccentric exercise.
TLDR
The decrease in glutamine suggests that the metabolism of the muscle may be affected by this exercise, however, the occurrence of this decrease in both groups suggests that this change was not a response to muscle damage.
Dosing and efficacy of glutamine supplementation in human exercise and sport training.
  • M. Gleeson
  • Biology, Medicine
    The Journal of nutrition
  • 2008
TLDR
Although glutamine is essential for lymphocyte proliferation, the plasma glutamine concentration does not fall sufficiently low after exercise to compromise the rate of proliferation and the suggested reasons for taking glutamine supplements have received little support from well-controlled scientific studies in healthy, well-nourished humans.
Glutamine supplementation further enhances exercise-induced plasma IL-6.
TLDR
It is hypothesized that glutamine supplementation would attenuate the exercise-induced decrease in plasma glutamine concentration and, thus, further enhance levels of plasma IL-6.
No effect of glutamine supplementation and hyperoxia on oxidative metabolism and performance during high-intensity exercise
TLDR
The data show no effect of glutamine ingestion either alone or in combination with hyperoxia, and thus no limiting effect of the tricarboxylic acid intermediate pool size, on oxidative metabolism and performance during maximal exercise.
Effects of acute exhaustive physical exercise upon glutamine metabolism of lymphocytes from trained rats.
The effects of oral glutamine supplementation on athletes after prolonged, exhaustive exercise.
EFFECT OF EXERCISE ON GLUTAMINE SYNTHESIS AND TRANSPORT IN SKELETAL MUSCLE FROM RATS
TLDR
The effects of exercise on glutamine synthesis and transport in rat skeletal muscle is investigated and the decrease in plasma glutamine concentration in EX‐1 is not mediated by GS or glutamine transport in skeletal muscle, however, 24 h after exercise, lower GS may contribute to the decreases in glutamines concentration in muscle.
Glutamine protects against increases in blood ammonia in football players in an exercise intensity-dependent way
TLDR
The results suggest that chronically supplemented Gln protects against exercise-induced hyperammonemia depending on exercise intensity and supplementation duration.
Growth hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients.
TLDR
It is concluded that the anticatabolic action of rhGH is associated with a potentially harmful decrease in muscle glutamine production after trauma, and glutamine synthetase mRNA levels increased after rhGH infusion, possibly to compensate for reduced glutamine precursor availability.
...
1
2
3
4
5
...