Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.

@article{Bgel2007EffectOP,
  title={Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women.},
  author={Susanne H B{\"u}gel and Anne D S{\o}rensen and Ole Holm Hels and Mette Kristensen and Cees Vermeer and Jette Jakobsen and Albert Flynn and Christian M{\o}lgaard and Kevin D. Cashman},
  journal={The British journal of nutrition},
  year={2007},
  volume={97 2},
  pages={
          373-80
        }
}
While current intakes of phylloquinone (vitamin K1) in many populations are believed to be sufficient to maintain normal blood coagulation, these may be insufficient to cover the requirements for optimal bone metabolism. Therefore, the objective of the present study was to investigate the effect of increasing phylloquinone intakes above the usual dietary intake for 6 weeks on biochemical markers of vitamin K status and bone turnover in postmenopausal women. Thirty-one postmenopausal women… 
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33 Citations
Background Citations
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Methods Citations
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Results Citations
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33 Citations

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Citation Type

Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women
TLDR
Six weeks supplementation with a dose of phylloquinone similar to that obtainable from the diet induced a deterioration of the lipid profile with no improvement in any of the other risk markers analysed, suggesting that results do not support a cardioprotective effect of vitamin K.
Vitamin K and osteoporosis: Myth or reality?
Vitamin K and bone health in adult humans.
  • S. Bügel
  • Biology, Medicine
    Vitamins and hormones
  • 2008
Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population
TLDR
Consumption of a yogurt drink fortified with low doses of among others MK-7 for 3 months significantly improved vitamin K status in a healthy population.
Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study
TLDR
The geniVida™ bone blend (GBB) may help to prevent osteoporosis and reduce fracture risk, at least at the hip, in postmenopausal women.
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women
TLDR
MK-7 supplements may help postmenopausal women to prevent bone loss and be extended to other populations, e.g., children and men, because of the longer half-life and greater potency of the long-chain MK-7.
Relationship between vitamin K status, bone mineral density, and hs-CRP in young Korean women
TLDR
It is concluded that sufficient intake of vitamin K is required to secure peak bone mass in young adult women and affect inflammatory status andBone mineral density was negatively correlated with vitamin K deficiency status and status of vitaminK affectsinflammatory status and bone formation.
Dietary vitamins K1, K2 and bone mineral density: the Hordaland Health Study
TLDR
The results do not support dietary intake of vitamins K1 or K2 as being major determinants of BMD, and future studies should investigate possible associations between intake of vitamin K1, K2 and fracture risk.
Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight.
TLDR
It is demonstrated that a high vitamin K status of bone has no effect on circulating adiponectin in healthy people and long-term vitamin K supplementation does not increase weight in healthy postmenopausal women.
Reduction Of Ovariectomy-induced Bone Loss In Rats By Menaquinone-4, Cholecalciferol, And (n-3) Polyunsaturated Fats
TLDR
Supraphysiological levels of menaquinone-4 did ameliorate the bone mineral loss associated with ovariectomization when used in conjunction with vitamin D or (n-3) PUFA.
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References

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TLDR
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TLDR
A daily phylloquinone intake of approximately 1000 micro g is required to maximally gamma-carboxylate circulating osteocalcin.
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TLDR
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TLDR
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