Effect of photodynamic therapy on normal fibroblasts and colon anastomotic healing in mice

@article{Haddad1999EffectOP,
  title={Effect of photodynamic therapy on normal fibroblasts and colon anastomotic healing in mice},
  author={Riad Haddad and Ofer Kaplan and Eli Brazovski and Micha Rabau and Schlomo Schneebaum and A. L. Shnaper and Yehuda Skornick and Hanoch Kashtan},
  journal={Journal of Gastrointestinal Surgery},
  year={1999},
  volume={3},
  pages={602-606}
}
Photodynamic therapy as an adjuvant modality to surgical resection of colon cancer is feasible provided that it does not affect healing of the anastomosis. The aim of this study was to evaluate the effects of photodynamic therapy on the viability of normal fibroblasts and on the healing process of colonic anastomosis in mice. Both in vitro and in vivo methods were employed. For in vitro study, 2 x 105 human fibroblasts were incubated in triplicate with 5-aminolevulinic acid (2.5 μ g/well) for… CONTINUE READING