Effect of phosphorylation on alpha B-crystallin: differences in stability, subunit exchange and chaperone activity of homo and mixed oligomers of alpha B-crystallin and its phosphorylation-mimicking mutant.

@article{Ahmad2008EffectOP,
  title={Effect of phosphorylation on alpha B-crystallin: differences in stability, subunit exchange and chaperone activity of homo and mixed oligomers of alpha B-crystallin and its phosphorylation-mimicking mutant.},
  author={Md. Faiz Ahmad and Bakthisaran Raman and Tangirala Ramakrishna and Ch Mohan Rao},
  journal={Journal of molecular biology},
  year={2008},
  volume={375 4},
  pages={1040-51}
}
Phosphorylation appears to be one of the modulators of chaperone functions of small heat shock proteins. However, the role of phosphorylation is not completely understood. We have investigated the structural and functional consequences of a phosphorylation-mimicking mutation in alpha B-crystallin, a small heat shock protein with chaperone activity. We have… CONTINUE READING