Effect of phospholipid surface charge on the conductance and gating of a Ca2+-activated K+ channel in planar lipid bilayers

@article{Moczydlowski1985EffectOP,
  title={Effect of phospholipid surface charge on the conductance and gating of a Ca2+-activated K+ channel in planar lipid bilayers},
  author={Edward G. Moczydlowski and Osvaldo Alvarez and Cecilia Vergara and Ram{\'o}n Latorre},
  journal={The Journal of Membrane Biology},
  year={1985},
  volume={83},
  pages={273-282}
}
A Ca-activated, K-selective channel from plasma membrane of rat skeletal muscle was studied in artificial lipid bilayers formed from either phosphatidylethanolamine (PE) or phosphatidylserine (PS). In PE, the single-channel conductance exhibited a complex dependence on symmetrical K+ concentration that could not be described by simple Michaelis-Menten saturation. At low K+ concentrations the channel conductance was higher in PS membranes, but approached the same conductance observed in PE above… CONTINUE READING

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