• Corpus ID: 8393297

Effect of phospholipid on aldosterone biosynthesis by a cytochrome P-450(11) beta-reconstituted system.

  title={Effect of phospholipid on aldosterone biosynthesis by a cytochrome P-450(11) beta-reconstituted system.},
  author={T. Ohnishi and Akira Wada and Yasuki Nonaka and Mitsuhiro Okamoto and Toshio Yamano},
  journal={Biochemistry international},
  volume={9 6},
Effect of phospholipid on aldosterone synthesis catalyzed by a cytochrome P-450(11)beta-reconstituted system was examined. Corticosterone was incubated with P-450(11)beta in the presence of phosphatidylcholine, phosphatidylethanolamine, cardiolipin, phosphatidylinositol, or phosphatidylserine. These phospholipids stimulated the rate of aldosterone- and 18-hydroxycorticosterone-synthesis, although the mode of stimulation by neutral phospholipids was different from that by acidic phospholipids… 

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