• Chemistry, Medicine
  • Published in Biochemistry international 1984

Effect of phospholipid on aldosterone biosynthesis by a cytochrome P-450(11) beta-reconstituted system.

@article{Ohnishi1984EffectOP,
  title={Effect of phospholipid on aldosterone biosynthesis by a cytochrome P-450(11) beta-reconstituted system.},
  author={Tomoko Ohnishi and Atsushi Wada and Yasuki Nonaka and Mitsuhiro Okamoto and Toshio Yamano},
  journal={Biochemistry international},
  year={1984},
  volume={9 6},
  pages={
          715-23
        }
}
Effect of phospholipid on aldosterone synthesis catalyzed by a cytochrome P-450(11)beta-reconstituted system was examined. Corticosterone was incubated with P-450(11)beta in the presence of phosphatidylcholine, phosphatidylethanolamine, cardiolipin, phosphatidylinositol, or phosphatidylserine. These phospholipids stimulated the rate of aldosterone- and 18-hydroxycorticosterone-synthesis, although the mode of stimulation by neutral phospholipids was different from that by acidic phospholipids… CONTINUE READING

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