Effect of phorbol ester on vagal stimulation and acetylcholine-evoked exocrine pancreatic secretion and cytosolic free calcium in the rat.

Abstract

In anaesthetized rats, interaction between either vagal stimulation or acetylcholine (ACh) and the phorbol ester, 12-0-tetradecanoylphorbol-13-acetate (TPA) and staurosporine on pancreatic juice secretion have been investigated in vivo. In vitro, rat cytosolic free calcium concentration (Ca2+)i in pancreatic acini loaded with the fluorescent dye, Fura-2… (More)

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