Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations.

@article{Pertwee1995EffectOP,
  title={Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations.},
  author={Roger G Pertwee and Susanthi R. Fernando and Graeme Griffin and V Abadji and Alexandros Makriyannis},
  journal={European journal of pharmacology},
  year={1995},
  volume={272 1},
  pages={73-8}
}
The endogenous cannabinoid receptor ligand, anandamide, produced a concentration related inhibition of electrically evoked contractions of the guinea-pig myenteric plexus preparation. Its potency was markedly enhanced by phenylmethylsulphonyl fluoride (2.0-200 microM) which presumably acts by inhibiting the hydrolysis of anandamide in this preparation. The degree of this potentiation increased with the concentration of phenylmethylsulphonyl fluoride used. The methyl analogue of anandamide, R… CONTINUE READING

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