Effect of phenethyl isothiocyanate on the metabolism of tobacco-specific nitrosamines by cultured rat oral tissue.

@article{Murphy1991EffectOP,
  title={Effect of phenethyl isothiocyanate on the metabolism of tobacco-specific nitrosamines by cultured rat oral tissue.},
  author={Sharon E Murphy and Rachel Heiblum and Peter G. King and Dennis J Bowman and William J. Davis and Gary David Stoner},
  journal={Carcinogenesis},
  year={1991},
  volume={12 6},
  pages={957-61}
}
The effect of phenethyl isothiocyanate (PEITC) on the metabolism of N'-nitrosonornicotine (NNN) and 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cultured rat oral tissue was investigated. Two protocols were used. In one, oral tissue from untreated rats was cultured in the presence of 10 or 50 microM PEITC and either NNN or NNK. The levels of NNN and NNK metabolites released into the culture media were determined by HPLC analysis. The presence of 10 microM PEITC inhibited the… CONTINUE READING

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