Effect of pharmacological daytime doses of melatonin on human mood and performance

  title={Effect of pharmacological daytime doses of melatonin on human mood and performance},
  author={Andrew B. Dollins and Harry J. Lynch and Richard J. Wurtman and Mei Hua Deng and Karl U. Kischka and Ray E. Gleason and Harris R. Lieberman},
Melatonin (10, 20, 40, or 80 mg, PO) or placebo was administered at 1145 hours on five separate occasions to 20 healthy male volunteers and the effects on serum melatonin levels, mood, performance, and oral temperature were monitored. Subjects were studied between 0930 and 1700 hours. A battery of interactive computer tasks designed to assess performance and mood was completed, oral temperature was measured, and blood samples were taken for serum melatonin radioimmunoassay. The areas under the… CONTINUE READING

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