Effect of phage infection on toxin production by Clostridium difficile.

  title={Effect of phage infection on toxin production by Clostridium difficile.},
  author={Shan Goh and Barbara J. Chang and Thomas V Riley},
  journal={Journal of medical microbiology},
  volume={54 Pt 2},
Infection with Clostridium difficile and subsequent production of toxins A and B may result in C. difficile-associated diarrhoea and pseudomembranous colitis in hospital patients. The effect of four temperate phages, obtained by induction of clinical C. difficile isolates, on toxin production by C. difficile was determined. None of these phages converted a lysogenized non-toxigenic C. difficile strain to toxin production. One of the accessory toxin genes, tcdE, was detected in three phages… CONTINUE READING

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Cloning: a Laboratory Manual, 2nd edn

  • J. Sambrook, E. F. Fritsch, T. Maniatis
  • Cold Spring Harbor,
  • 1989
Highly Influential
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