Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension.

@article{Iglarz2003EffectOP,
  title={Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension.},
  author={Marc Iglarz and Rhian M Touyz and Farhad Abbassi Amiri and M R Lavoie and Quy N. Diep and Ernesto L Schiffrin},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 1},
  pages={45-51}
}
OBJECTIVE Peroxisome proliferator-activated receptors (PPARs) may modulate in vitro the vascular production of vasoactive peptides such as endothelin-1 (ET-1). Thus, we investigated in vivo the interaction between PPARs and ET-1 in deoxycorticosterone acetate (DOCA)-salt rats that overexpress vascular ET-1. METHODS AND RESULTS Unilaterally nephrectomized 16-week-old Sprague-Dawley rats (Uni-Nx) were divided into 4 groups (n=6 each): control group, DOCA-salt group, DOCA-salt+PPAR-gamma… CONTINUE READING
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