Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin.

@article{Malacoff1975EffectOP,
  title={Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin.},
  author={R F Malacoff and Fredric O. Finkelstein and Vincent T. Andriole},
  journal={Antimicrobial agents and chemotherapy},
  year={1975},
  volume={8 5},
  pages={574-80}
}
The pharmacokinetics of tobramycin and clindamycin were examined in patients undergoing peritoneal dialysis for chronic renal failure. Peak serum levels of tobramycin in functionally anephric patients were less than expected, probably secondary to a larger volume of distribution. Peritoneal dialysis resulted in a significant clearance of tobramycin, with a resultant reduction in serum half-life. The present data suggest that, if bactericidal serum levels of tobramycin are to be maintained in… CONTINUE READING

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