Effect of perfluorochemicals on BCNU chemotherapy: preliminary study in a rat brain tumor model.

@article{Kokunai1982EffectOP,
  title={Effect of perfluorochemicals on BCNU chemotherapy: preliminary study in a rat brain tumor model.},
  author={Takashi Kokunai and Keiichi Kuwamura},
  journal={Surgical neurology},
  year={1982},
  volume={18 4},
  pages={258-61}
}
This preliminary study was undertaken to identify the combined efficacy of perfluorochemicals (Fluosol-43) and a chemotherapeutic agent (BCNU) in a rat brain tumor model. The brain tumor model was produced by the intracerebral transplantation of C6 rat glioma cells. Fluosol-43 plus BCNU in an oxygen environment produced a significant prolongation of mean survival time compared to that of BCNU treatment alone. Perfluorochemicals (Fluosol-43) seem to have some synergistic effect on BCNU… CONTINUE READING