Effect of pentylenetetrazole and sound stimulation induced single and repeated convulsive seizures on the MDA, GSH and NO levels, and SOD activities in rat liver and kidney tissues.

@article{Dillioglugil2010EffectOP,
  title={Effect of pentylenetetrazole and sound stimulation induced single and repeated convulsive seizures on the MDA, GSH and NO levels, and SOD activities in rat liver and kidney tissues.},
  author={Meltem Ozlen Dillioglugil and Hale Maral Kir and Cennet Gural Demir and Gul Ilbay and Deniz G{\"o}ren Şahin and Ozdal Dillioğlugil and Gonul Bambal and Haluk Mekik and Nurbay Ates},
  journal={Brain research bulletin},
  year={2010},
  volume={83 6},
  pages={356-9}
}
OBJECTIVES the aim of our study was to evaluate the activity of superoxide dismutase (SOD) and the levels of glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) in liver and kidney tissues in a rat model of convulsive seizure induced by single and repeated doses of pentylenetetrazole (PTZ) and sound stimulation with key ringing. MATERIALS AND METHODS male Wistar adult rats (n=48), were used in the experiment. The animals were divided into six groups: (1) Single Seizure Control… CONTINUE READING

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