Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis.

@article{Nelson1999EffectOP,
  title={Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis.},
  author={Jeffrey L. Nelson and James W. Alexander and J X Mao and T Vohs and Cora K. Ogle},
  journal={Critical care medicine},
  year={1999},
  volume={27 1},
  pages={113-9}
}
OBJECTIVE Septic animals receiving high-protein liquid diets have increased mortality and increased production of cytokines by the gut compared with animals receiving low-protein diets. The purpose of this study was to evaluate the ability of pentoxifylline to alter gut cytokine production in a rat model of prolonged acute peritonitis, to determine its effect on survival in such animals, and to determine whether alteration of gut cytokine production was associated with survival. DESIGN… CONTINUE READING

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