Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses.

Abstract

OBJECTIVE To compare effects of a single dose of pentoxifylline (PTX), flunixin meglumine (FM), and their combination (FM/PTX) in a model of equine endotoxemia. ANIMALS 24 healthy horses, aged 2 to 15 years. PROCEDURE 4 groups (n = 6/group) received 30 ng of Escherichia coli O55:B5 endotoxin/kg of body weight, i.v., over 30 minutes, and 1 of the… (More)

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