Effect of partial hepatectomy of the responsiveness of microsomal enzymes and cytochrome P-450 to phenobarbital or 3-methylcholanthrene.

@article{Gram1968EffectOP,
  title={Effect of partial hepatectomy of the responsiveness of microsomal enzymes and cytochrome P-450 to phenobarbital or 3-methylcholanthrene.},
  author={Theodore E. Gram and Anthony M. Guarino and Frank E. Greene and Philippe Gigon and James R. Gillette},
  journal={Biochemical pharmacology},
  year={1968},
  volume={17 9},
  pages={
          1769-78
        }
}
An induction of heme oxygenase and its possible relation to the decrease of cytochrome P-450 content during liver regeneration.
TLDR
The results suggest that the inverse relationship between the increase of heme oxygenase activity and the decrease of cytochrome P-450 content would be a biochemical phenomenon seen in regenerating liver and that the phenomenon would not be simply due to the surgical stress to the animals.
Effects of tetrachlorvinphas on hepatic microsomal enzymes in the rat
TLDR
The results demonstrated that repeated administration of TCVP might induce the activity of hepatic microsomal enzymes in rats, and suggested that the inducing effect of TC VP could be explained by accelerating synthesis ofmicrosomal protein.
Effect of partial liver resection and phenobarbital on the restoration of impaired drug metabolism in carbon tetrachloride induced liver damage.
  • M. Vorne
  • Chemistry, Biology
    Acta pharmacologica et toxicologica
  • 1971
TLDR
Restoration of p-nitrophenol conjugation was very rapid in the resected animals and 10 days after the liver resection there were no significant differences between the operated groups and unoperated saline controls.
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