Effect of parathyroid hormone on the connecting tubule from the rabbit kidney: biphasic response of transmural voltage

@article{Shimizu1990EffectOP,
  title={Effect of parathyroid hormone on the connecting tubule from the rabbit kidney: biphasic response of transmural voltage},
  author={Toshikatsu Shimizu and Koji Yoshitomi and Masuhisa Nakamura and Masashi Imai},
  journal={Pfl{\"u}gers Archiv},
  year={1990},
  volume={416},
  pages={254-261}
}
The effect of parathyroid hormone (PTH) on ion transport was examined by observing transmural (V T) and basolateral membrane voltage (V B) in the in vitro perfused rabbit connecting tubule. Addition of 10 nmol/l PTH to the bath induced a biphasic response of V T, with hyperpolarization followed by depolarization. Chlorophenylthioadenosine cyclic 3′,5′-monophosphate mimicked the effect of PTH, which did not change the V B in the connecting tubule cell, but mainly caused changes in the apical… CONTINUE READING