Effect of papaverine on synaptic transmission in the guinea-pig ileum.

@article{Izzo1997EffectOP,
  title={Effect of papaverine on synaptic transmission in the guinea-pig ileum.},
  author={Angelo A Izzo and Nicola Mascolo and Marcello Thiry Comicholi da Costa and Francesco Capasso},
  journal={British journal of pharmacology},
  year={1997},
  volume={121 4},
  pages={768-72}
}
1. The effect of papaverine, a well known smooth muscle relaxant, was investigated on neural transmission within the enteric nervous system. Segments of guinea-pig ileum were placed in a partitioned bath to enable drugs, including papaverine, to be applied to enteric nerve pathways without interfering with the recording of the smooth muscle contraction. Ascending excitatory enteric nerve pathways were activated by electrical field stimulation in the anal compartment (10 Hz for 2 s, 45 mA, 0.5… CONTINUE READING

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