Effect of panitumumab on autophagy in colon cancer.

  title={Effect of panitumumab on autophagy in colon cancer.},
  author={Haralabos P Kalofonos and Anna Antonacopoulou and Panagiota Matsouka and Efstathia Giannopoulou},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={27 15\_suppl},
e22151 Background: Panitumumab, a human monoclonal antibody raised against EGFR, has been approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) for the treatment of patients with EGFR-expressing mCRC and wild type kras. The ratio of reduced/oxidised form of glutathione (GSH/GSSG) is an indicator of the redox status in cells. The aim of the current study was to investigate the effect of panitumumab on the redox status of colon cancer cell lines Caco-2, DLD-1… Expand
Paradoxical action of reactive oxygen species in creation and therapy of cancer.
A general overview and rationale of paradoxical action of ROS in creation and therapy of cancer, tests to be used, and examples of how it may be applied are presented. Expand