Effect of pancreas transplantation on glucose counterregulation in insulin-dependent diabetic patients prone to severe hypoglycaemia.

@article{Bolinder1991EffectOP,
  title={Effect of pancreas transplantation on glucose counterregulation in insulin-dependent diabetic patients prone to severe hypoglycaemia.},
  author={Jan Bolinder and Hans Wahrenberg and Anna Persson and Beverly Linde and Gunnar Tyd{\'e}n and Carl Gustav Groth and Jan Ostman},
  journal={Journal of internal medicine},
  year={1991},
  volume={230 6},
  pages={527-33}
}
Pancreatic transplantation was performed in three patients with insulin-dependent diabetes mellitus in whom recurrent and severe episodes of hypoglycaemia had been found to be due to defective glucose counterregulation. Thus in these patients the spontaneous blood glucose recovery after insulin-induced hypoglycaemia (0.1 U kg-1 h-1 i.v. insulin until blood glucose levels fell below 2.8 mmol l-1) was delayed, and the responses of glucagon, epinephrine and growth hormone (GH) were absent or… CONTINUE READING