Effect of paf antagonists on the cytotoxic activity of antineoplastic ether phospholipids.

@article{Diomede1993EffectOP,
  title={Effect of paf antagonists on the cytotoxic activity of antineoplastic ether phospholipids.},
  author={Luisa Diomede and P P Principe and Maria Domingo and Colette Broquet and P Chabrier and Pierre G. Braquet and Mario Salmona},
  journal={International journal of oncology},
  year={1993},
  volume={2 5},
  pages={777-80}
}
The capability of the methoxy-substituted 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3 or Edelfosine) and the two aza-alkylphospholipids BN 52205 and BN 52211 to bind to the PAF receptor was analysed in rabbit platelet membranes. Ether phospholipid concentrations were tested between 10(-5) M and 10(-11) M. The results indicate that… CONTINUE READING