Effect of pH on the transport of Krebs cycle intermediates in renal brush border membranes.

@article{Wright1982EffectOP,
  title={Effect of pH on the transport of Krebs cycle intermediates in renal brush border membranes.},
  author={Stephen H. Wright and Ian Kippen and Ernest M Wright},
  journal={Biochimica et biophysica acta},
  year={1982},
  volume={684 2},
  pages={287-90}
}
Lowering extravesicular pH stimulated Na+-dependent citrate transport in renal brush border membrane vesicles: e.g., at pHout = 5.5, the initial rate of citrate uptake was increased 10-fold compared to parallel control experiments at pH 7.5. The same experimental conditions had little effect on succinate uptake. The influence of pH on citrate transport is a product of the extravesicular H+ concentration; pH gradients did not potentiate the effects nor were proton gradients capable of driving… CONTINUE READING