Effect of pH on the ocular distribution of a topical carbonic anhydrase inhibitor.

Abstract

Ampholyte carbonic anhydrase inhibitors (including MK-927) have previously been shown to elicit greater intraocular pressure reduction when applied in ionized form at moderately acidic or alkaline pH compared to application of un-ionized drug at neutral pH. Since ionized solutions should be far more membrane-impermeant than un-ionized solutions, we… (More)

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Cite this paper

@article{Conroy1995EffectOP, title={Effect of pH on the ocular distribution of a topical carbonic anhydrase inhibitor.}, author={Celine Conroy and Thomas H. Maren}, journal={Experimental eye research}, year={1995}, volume={61 2}, pages={213-22} }