Effect of pH on the myocardial uptake and pharmacodynamics of propafenone in the isolated rabbit heart.

@article{Gillis1988EffectOP,
  title={Effect of pH on the myocardial uptake and pharmacodynamics of propafenone in the isolated rabbit heart.},
  author={Anne Gillis and Robert E. Kates},
  journal={Journal of cardiovascular pharmacology},
  year={1988},
  volume={12 5},
  pages={526-34}
}
The influence of pH on the myocardial disposition of propafenone was studied in isolated perfused rabbit hearts. Five pH groups were evaluated: pH 7.0, 7.2, 7.4, 7.6, and 7.8. Hearts were perfused with a modified Krebs-Henseleit buffer containing approximately 100 ng/ml propafenone. Myocardial propafenone accumulation was determined from differences in the aortic perfusate and coronary sinus effluent propafenone concentrations. The myocardial accumulation of propafenone was significantly pH… CONTINUE READING