Effect of pEgr-TNFalpha gene radiotherapy on mice melanoma.

  title={Effect of pEgr-TNFalpha gene radiotherapy on mice melanoma.},
  author={Cong-mei Wu and Xiu-yi Li and Mei Tian},
  journal={Melanoma research},
  volume={15 3},
In the present study, we constructed a pEgr-tumour necrosis factor-alpha (TNFalpha) plasmid and investigated its expression properties in B16 cells on exposure to ionizing irradiation and, furthermore, the effect of gene radiotherapy on a melanoma model. Firstly, the recombinant pEgr-TNFalpha plasmid was constructed and transfected into B16 cells with liposomes to investigate its expression properties on exposure to X-irradiation. The melanoma-bearing model was then established and the tumour… Expand