Effect of oxygen tension on HeLa cell growth.

@article{Rueckert1960EffectOO,
  title={Effect of oxygen tension on HeLa cell growth.},
  author={Roland R. Rueckert and Gisela C. Mueller},
  journal={Cancer research},
  year={1960},
  volume={20},
  pages={
          944-9
        }
}
High oxygen concentrations were shown to have a powerful growth-inhibitory effect on HeLa cultures. Initially there was a generalized reduction in the rate of cell division and in the biosynthesis of DNA, RNA, and protein, a shift in glucose metabolism to a completely anaerobic pattern, and an accompanying acceleration in the rate of glucose utilization. After about one generation time cell division ceased completely. Finally, after about 36 hours the lethal effect of the oxygen lesion was… CONTINUE READING

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