Effect of oxidative stress on the release of [3H]GABA in cultured chick retina cells.

Abstract

The effect of ascorbate (1.5 mM)/Fe2+ (7.5 microM)-induced oxidative stress on the release of pre-accumulated [3H]gamma-aminobutyric acid ([3H]GABA) from cultured chick retina cells was studied. Depolarization of control cells with 50 mM K+ increased the release of [3H]GABA by 1.01 +/- 0.16% and 2.5 +/- 0.3% of the total, in the absence and in the presence… (More)

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