Corpus ID: 38903173

Effect of oxatomide on calcium ions in smooth muscle.

  title={Effect of oxatomide on calcium ions in smooth muscle.},
  author={M de L Arruzazabala Valma{\~n}a and Ricardo Gonzalez Alvarez},
  journal={Allergologia et immunopathologia},
  volume={14 3},
In an attempt to elucidate the mechanism of inhibitory action of oxatomide on smooth muscle against various spasmogens, we studied the effect of this drug on cumulative dose response curves (CDRC) to CaCl2 in guinea pig ileum. We found that oxatomide induces a shift to right and a non-surmountable depression of the maximal response of these CDRC which suggests non-competitive antagonism. Furthermore, oxatomide inhibits 45Ca2+ uptake by guinea pig ileum after acetylcholine stimulation which… Expand