Effect of overall feedback inhibition in unbranched biosynthetic pathways.

  title={Effect of overall feedback inhibition in unbranched biosynthetic pathways.},
  author={Rui Alves and Michael A. Savageau},
  journal={Biophysical journal},
  volume={79 5},
We have determined the effects of control by overall feedback inhibition on the systemic behavior of unbranched metabolic pathways with an arbitrary pattern of other feedback inhibitions by using a recently developed numerical generalization of Mathematically Controlled Comparisons, a method for comparing the function of alternative molecular designs. This method allows the rigorous determination of the changes in systemic properties that can be exclusively attributed to overall feedback… CONTINUE READING
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