Effect of ovariectomy and estradiol replacement on skeletal muscle enzyme activity in female rats.

@article{Beckett2002EffectOO,
  title={Effect of ovariectomy and estradiol replacement on skeletal muscle enzyme activity in female rats.},
  author={Travis Beckett and Andr{\'e} Tchernof and Michael J. Toth},
  journal={Metabolism: clinical and experimental},
  year={2002},
  volume={51 11},
  pages={1397-401}
}
In female rats, ovariectomy (OVX) is associated with increased body fat and insulin resistance, and estradiol replacement prevents these alterations. These metabolic changes related to the estrogen-deficient state might be due, in part, to alterations in skeletal muscle substrate metabolism. We tested the hypothesis that estradiol affects the regulation of enzymes involved in substrate oxidation and storage within skeletal muscle. Specifically, we examined enzymes involved in the regulation of… CONTINUE READING

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