Effect of ovarian hormones on periodical changes in immune resistance associated with estrous cycle in the beagle bitch.

@article{Sugiura2004EffectOO,
  title={Effect of ovarian hormones on periodical changes in immune resistance associated with estrous cycle in the beagle bitch.},
  author={Kikuya Sugiura and Mami Nishikawa and Kayoko Ishiguro and Tomoko Tajima and Muneo Inaba and Ryuzo Torii and Shingo Hatoya and Viskam Wijewardana and Daijiro Kumagai and H. Tamada and Tsutomu Sawada and Susumu Ikehara and Toshio Inaba},
  journal={Immunobiology},
  year={2004},
  volume={209 8},
  pages={619-27}
}
In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific onset of pyometra, peripheral blood mononuclear cells (PBMNCs) were collected from beagle bitches during different stages of the estrous cycle and examined using various immunological… CONTINUE READING

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