Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus.

Abstract

We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2… (More)
DOI: 10.1089/vim.2008.0054

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