Effect of osmolality on aldosterone secretion.

  title={Effect of osmolality on aldosterone secretion.},
  author={Edward G Schneider and Karen J Radke and D A Ulderich and Robert Edward Taylor},
  volume={116 4},
The purpose of these experiments was to determine if the powerful effect of sodium chloride concentration on angiotensin II- and potassium-stimulated aldosterone secretion by isolated perfused adrenal glands is mediated by the sodium or chloride ion or by the obligatory change in osmolality. We used isolated Ringer's bicarbonate perfused canine adrenal gland preparations to determine the effects of a variety of isosmotic, hyperosmotic, and hyposmotic solutions on angiotensin II- and potassium… CONTINUE READING